The bio-pharmaceutical market is growing at fast rate based on new and improved drug formulations that are being developed and launched on an ongoing basis. A large part of these products are highly temperature sensitive, requiring refrigeration within specific temperature ranges for transport and storage of the drugs. CoolVu Time Temperature Indicators have been formulated to monitor the aggregate temperature history of these products, ensuring maximum efficacy at the time of administration of the drug to the patient, by providing the health care worker and/or the patient with a clear, visual indication as to the temperature related integrity of the product.